Interleukin-10 Producing T Lymphocytes Attenuate Dermal Scarring.

ABSTRACT:

Objective

Demonstrate the impact of IL-10 producing T lymphocytes on mediating dermal scarring.

Summary background data

We demonstrated that CD4+ cells are essential to improving postinjury wound healing and preventing fibrosis. CD4+ subsets secrete differential cytokine and growth factor profiles, though their role in fibrosis is not known. IL-10, a key anti-inflammatory cytokine shown to promote regenerative wound healing, is secreted by some CD4+ subsets. We, therefore, hypothesize that IL-10 producing CD4+ T lymphocyte subsets selectively attenuate dermal wound fibrosis.

Methods

IL-10-/- and wild-type murine splenocytes were enriched for CD4+ lymphocytes and adoptively transferred into severe combined immunodeficient (SCID) mice that received full-thickness wounds

SUBMITTER: Short WD 

PROVIDER: S-EPMC8428868 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature