Predicting major adverse limb events in individuals with type 2 diabetes: Insights from the EXSCEL trial.

ABSTRACT:

Aims

Although models exist to predict amputation among people with type 2 diabetes with foot ulceration or infection, we aimed to develop a prediction model for a broader range of major adverse limb events (MALE)-including gangrene, revascularization and amputation-among individuals with type 2 diabetes.

Methods

In a post-hoc analysis of data from the Exenatide Study of Cardiovascular Event Lowering (EXSCEL) trial, we compared participants who experienced MALE with those who did not. A multivariable model was constructed and translated into a risk score.

Results

Among the 14,752 participants with type 2 diabetes in EXSCEL, 3.6% experienced MALE. Characteristics associated with increased risk of MALE were peripheral artery disease (PAD) (HR_adj 4.83, 95% CI:

SUBMITTER: Weissler EH 

PROVIDER: S-EPMC8429063 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature