Cytokine-specific autoantibodies shape the gut microbiome in autoimmune polyendocrine syndrome type 1.

ABSTRACT:

Background

Gastrointestinal dysfunction is a frequent and disabling manifestation of autoimmune polyendocrine syndrome type 1 (APS-1), a rare monogenic multiorgan autoimmune disease caused by the loss of central AIRE-controlled immune tolerance.

Objectives

This study aimed to understand the role of the gut microbiome in APS-1 symptoms and potentially alleviate common gastrointestinal symptoms by probiotic intervention.

Methods

This study characterized the fecal microbiomes of 28 patients with APS-1 and searched for associations with gastrointestinal symptoms, circulating anti-cytokine autoantibodies, and tryptophan-related metabolites. Additionally, daily doses of the probiotic Lactobacillus rhamnosus GG were administered for 3 months.

Results

Of 581 metagenomi

SUBMITTER: Petersen AO 

PROVIDER: S-EPMC8429070 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature