Evaluating Sleep Disturbances in Children With Rare Genetic Neurodevelopmental Syndromes.

ABSTRACT:

Background

Adequate sleep is important for proper neurodevelopment and positive health outcomes. Sleep disturbances are more prevalent in children with genetically determined neurodevelopmental syndromes compared with typically developing counterparts. We characterize sleep behavior in Rett (RTT), Angelman (AS), and Prader-Willi (PWS) syndromes to identify effective approaches for treating sleep problems in these populations. We compared sleep-related symptoms across individuals with these different syndromes with each other, and with typically developing controls.

Methods

Children were recruited from the Rare Diseases Clinical Research Network consortium registries; unaffected siblings were enrolled as related controls. For each participant, a parent completed multiple slee

SUBMITTER: Veatch OJ 

PROVIDER: S-EPMC8429141 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature