Late-onset kidney failure in survivors of childhood cancer: a report from the Childhood Cancer Survivor Study.

ABSTRACT:

Background

The incidence of and risk factors for late-onset kidney failure among survivors over the very long term remains understudied.

Materials and methods

A total of 25,530 childhood cancer survivors (median follow-up 22.3 years, interquartile range 17.4-28.8) diagnosed between 1970 and 1999, and 5045 siblings from the Childhood Cancer Survivor Study were assessed for self-reported late-onset kidney failure, defined as dialysis, renal transplantation, or death attributable to kidney disease. Piecewise exponential models evaluated associations between risk factors and the rate of late-onset kidney failure.

Results

A total of 206 survivors and 10 siblings developed late-onset kidney failure, a 35-year cumulative incidence of 1.7% (95% confidence interval [CI] = 1.4-

SUBMITTER: Dieffenbach BV 

PROVIDER: S-EPMC8429192 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature