Novel insights from fetal and placental phenotyping in 3 mouse models of Down syndrome.

ABSTRACT:

Background

In human fetuses with Down syndrome, placental pathology, structural anomalies and growth restriction are present. There is currently a significant lack of information regarding the early life span in mouse models of Down syndrome.

Objective

The objective of this study was to examine embryonic day 18.5 and placental phenotype in the 3 most common mouse models of Down syndrome (Ts65Dn, Dp(16)1/Yey, Ts1Cje). Based on prenatal and placental phenotyping in 3 mouse models of Down syndrome, we hypothesized that one or more of them would have a similar phenotype to human fetuses with trisomy 21, which would make it the most suitable for in utero treatment studies.

Study design

Here, C57BL6J/6 female mice were mated to Dp(16)1/Yey and Ts1Cje male mice and Ts65Dn fe

SUBMITTER: Adams AD 

PROVIDER: S-EPMC8429205 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature