Cerebrospinal fluid orexin in Alzheimer's disease: a systematic review and meta-analysis.

ABSTRACT:

Objective/background

A growing body of evidence suggests that sleep and Alzheimer's disease (AD) have a bi-directional relationship. Emerging research also suggests that orexin, a key neurotransmitter involved in sleep-wake regulation, may be altered in persons with AD, however results have not been consistent across prior studies. This investigation was conducted to both evaluate the aggregate literature to minimize the risk of bias and identify potential factors associated with heterogeneity across studies.

Methods

Systematic review identified relevant investigations that compared cerebrospinal fluid orexin in persons with AD and controls. Meta-analysis (random effects model) compared effect size (Hedge's g) for orexin between AD and controls. Meta-regression was additiona

SUBMITTER: Treu SP 

PROVIDER: S-EPMC8429218 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature