Age-related effects on thymic output and homeostatic T cell expansion following depletional induction in renal transplant recipients.

ABSTRACT: Thymic output and homeostatic mature cell proliferation both influence T cell repopulation following depletional induction, though the relative contribution of each and their association with recipient age have not been well studied. We investigated the repopulating T cell kinetics in kidney transplant recipients who underwent alemtuzumab induction followed by belatacept/rapamycin-based immunosuppression over 36-month posttransplantation. We focused specifically on the correlation between repopulating T cell subsets and the age of patients. Substantial homeostatic Ki67-expressing T cell proliferation was seen posttransplantation. A repertoire enriched for naïve T (T_Naïve ) cells emerged posttransplantation. Analysis by generalized estimating equation linear models revealed a str

SUBMITTER: Xu H 

PROVIDER: S-EPMC8429231 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature