Genetic susceptibility, obesity and lifetime risk of type 2 diabetes: The ARIC study and Rotterdam Study.

ABSTRACT:

Aims

Both lifestyle factors and genetic background contribute to the development of type 2 diabetes. Estimation of the lifetime risk of diabetes based on genetic information has not been presented, and the extent to which a normal body weight can offset a high lifetime genetic risk is unknown.

Methods

We used data from 15,671 diabetes-free participants of European ancestry aged 45 years and older from the prospective population-based ARIC study and Rotterdam Study (RS). We quantified the remaining lifetime risk of diabetes stratified by genetic risk and quantified the effect of normal weight in terms of relative and lifetime risks in low, intermediate and high genetic risk.

Results

At age 45 years, the lifetime risk of type 2 diabetes in ARIC in the low, intermediate

SUBMITTER: Ligthart S 

PROVIDER: S-EPMC8429251 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature