Diffusion along perivascular spaces reveals evidence supportive of glymphatic function impairment in Parkinson disease.

ABSTRACT:

Background

Reduced diffusion along perivascular spaces in adults with Alzheimer's-disease-related-dementias has been reported and attributed to reduced glymphatic function.

Objectives

To apply quantitative measures of diffusion along, and orthogonal to, perivascular spaces in a cohort of older adults with and without clinical symptoms of alpha-synuclein related neurodegeneration.

Methods

181 adults with Parkinson disease (PD) or essential tremor (ET) additionally sub-classified by the presence of cognitive impairment underwent 3 T MRI. Diffusion-tensor-imaging (spatial resolution = 2x2x2 mm; b-value = 1000 s/mm²; directions = 33) measures of diffusion (mm²/s) parallel and orthogonal to perivascular spaces at the level of the medullary veins, and

SUBMITTER: McKnight CD 

PROVIDER: S-EPMC8429254 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature