Probiotics combined with rifaximin influence the neurometabolic changes in a rat model of type C HE.

ABSTRACT: Type C hepatic encephalopathy (HE) is a neuropsychiatric disease caused by chronic liver disease. Management of type C HE remains an important challenge because treatment options are limited. Both the antibiotic rifaximin and probiotics have been reported to reduce the symptoms of HE, but longitudinal studies assessing their effects on brain metabolism are lacking and the molecular mechanisms underpinning their effects are not fully understood. Therefore, we evaluated in detail the effects of these different treatments on the neurometabolic changes associated with type C HE using a multimodal approach including ultra-high field in vivo ¹H MRS. We analyzed longitudinally the effect of rifaximin alone or in combination with the probiotic Vivomixx on the brain metabolic profile in

SUBMITTER: Flatt E 

PROVIDER: S-EPMC8429411 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature