Label-free microfluidic enrichment of cancer cells from non-cancer cells in ascites.

ABSTRACT: The isolation of a patient's metastatic cancer cells is the first, enabling step toward treatment of that patient using modern personalized medicine techniques. Whereas traditional standard-of-care approaches select treatments for cancer patients based on the histological classification of cancerous tissue at the time of diagnosis, personalized medicine techniques leverage molecular and functional analysis of a patient's own cancer cells to select treatments with the highest likelihood of being effective. Unfortunately, the pure populations of cancer cells required for these analyses can be difficult to acquire, given that metastatic cancer cells typically reside in fluid containing many different cell populations. Detection and analyses of cancer cells therefore require separation from th

SUBMITTER: Stone NE 

PROVIDER: S-EPMC8429413 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature