A Coupled Mechanobiological Model of Muscle Regeneration In Cerebral Palsy.

ABSTRACT: Cerebral palsy is a neuromusculoskeletal disorder associated with muscle weakness, altered muscle architecture, and progressive musculoskeletal symptoms that worsen with age. Pathological changes at the level of the whole muscle have been shown; however, it is unclear why this progression of muscle impairment occurs at the cellular level. The process of muscle regeneration is complex, and the interactions between cells in the muscle milieu should be considered in the context of cerebral palsy. In this work, we built a coupled mechanobiological model of muscle damage and regeneration to explore the process of muscle regeneration in typical and cerebral palsy conditions, and whether a reduced number of satellite cells in the cerebral palsy muscle environment could cause the muscle regenerati

SUBMITTER: Khuu S 

PROVIDER: S-EPMC8429491 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature