Endotype of allergic asthma with airway obstruction in urban children.

ABSTRACT:

Background

Black and Hispanic children growing up in disadvantaged urban neighborhoods have the highest rates of asthma and related morbidity in the United States.

Objectives

This study sought to identify specific respiratory phenotypes of health and disease in this population, associations with early life exposures, and molecular patterns of gene expression in nasal epithelial cells that underlie clinical disease.

Methods

The study population consisted of 442 high-risk urban children who had repeated assessments of wheezing, allergen-specific IgE, and lung function through 10 years of age. Phenotypes were identified by developing temporal trajectories for these data, and then compared to early life exposures and patterns of nasal epithelial gene expression at 11 year

SUBMITTER: Altman MC 

PROVIDER: S-EPMC8429519 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature