Internal and External Validation of an Alcohol Biomarker for Screening in Trauma.

ABSTRACT:

Objective

We aimed to examine biomarkers for screening unhealthy alcohol use in the trauma setting.

Summary and background data

Self-report tools are the practice standard for screening unhealthy alcohol use; however, their collection suffers from recall bias and incomplete collection by staff.

Methods

We performed a multi-center prospective clinical study of 251 adult patients who arrived within 24 hours of injury with external validation in another 60 patients. The Alcohol Use Disorders Identification Test served as the reference standard. The following biomarkers were measured: (1) PEth; (2) ethyl glucuronide; (3) ethyl sulfate; (4) gamma-glutamyl-transpeptidase; (5) carbohydrate deficient transferrin; and (6) blood alcohol concentration (BAC). Candidate single bio

SUBMITTER: Afshar M 

PROVIDER: S-EPMC8429522 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature