Ontology highlight
ABSTRACT:
SUBMITTER: Dao NC
PROVIDER: S-EPMC8429551 | biostudies-literature | 2021 Oct
REPOSITORIES: biostudies-literature
Dao Nigel C NC Brockway Dakota F DF Suresh Nair Malini M Sicher Avery R AR Crowley Nicole A NA
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20210610 11
Somatostatin (SST) neurons have been implicated in a variety of neuropsychiatric disorders such as depression and anxiety, but their role in substance use disorders, including alcohol use disorder (AUD), is not fully characterized. Here, we found that repeated cycles of alcohol binge drinking via the Drinking-in-the-Dark (DID) model led to hypoactivity of SST neurons in the prelimbic (PL) cortex by diminishing their action potential firing capacity and excitatory/inhibitory transmission dynamic. ...[more]