Correlations between autoantibodies and the ATR-FTIR spectra of sera from rheumatoid arthritis patients.

ABSTRACT: Rheumatoid arthritis (RA) is one of the most common autoimmune diseases worldwide. Due to high heterogeneity in disease manifestation, accurate and fast diagnosis of RA is difficult. This study analyzed the potential relationship between the infrared (IR) spectra obtained by attenuated total reflectance Fourier transform infrared spectroscopy (ATR-FTIR) and the presence of autoantibodies and antibodies against urease in sera. Additionally, the wave number of the IR spectrum that enabled the best differentiation between patients and healthy blood donors was investigated. Using a mathematical model involving principal component analysis and discriminant analysis, it was shown that the presence of anti-citrullinated protein antibody, rheumatoid factor, anti-neutrophil cytoplasmic antibodies,

SUBMITTER: Durlik-Popinska K 

PROVIDER: S-EPMC8429563 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature