Hemicentin-1 is an essential extracellular matrix component of the dermal-epidermal and myotendinous junctions.

ABSTRACT: The extracellular matrix architecture is composed of supramolecular fibrillar networks that define tissue specific cellular microenvironments. Hemicentins (Hmcn1 and Hmcn2) are ancient and very large members (> 600 kDa) of the fibulin family, whose short members are known to guide proper morphology and functional behavior of specialized cell types predominantly in elastic tissues. However, the tissue distribution and function of Hemicentins within the cellular microenvironment of connective tissues has remained largely unknown. Performing in situ hybridization and immunofluorescence analyses, we found that mouse Hmcn1 and Hmcn2 show a complementary distribution throughout different tissues and developmental stages. In postnatal dermal-epidermal junctions (DEJ) and myotendinous junctions (M

SUBMITTER: Welcker D 

PROVIDER: S-EPMC8429575 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature