Tracking of the biochemical changes upon pleomorphic adenoma progression using vibrational microspectroscopy.

ABSTRACT: Head and neck tumors can be very challenging to treat because of the risk of problems or complications after surgery. Therefore, prompt and accurate diagnosis is extremely important to drive appropriate treatment decisions, which may reduce the chance of recurrence. This paper presents the original research exploring the feasibility of Fourier transform infrared (FT-IR) and Raman spectroscopy (RS) methods to investigate biochemical alterations upon the development of the pleomorphic adenoma. Principal component analysis (PCA) was used for a detailed assessment of the observed changes and to determine the spectroscopic basis for salivary gland neoplastic pathogenesis. It is implied that within the healthy margin, as opposed to the tumoral tissue, there are parts that differ significantly in

SUBMITTER: Paluszkiewicz C 

PROVIDER: S-EPMC8429647 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature