Microwave ablation of primary breast cancer inhibits metastatic progression in model mice via activation of natural killer cells.

ABSTRACT: Surgery is essential for controlling the symptoms and complications of stage IV breast cancer. However, locoregional treatment of primary tumors often results in distant progression, including lung metastasis, the most common type of visceral metastasis. As a minimally invasive thermal therapy, microwave ablation (MWA) has been attempted in the treatment of breast cancer, but the innate immune response after MWA has not yet been reported. Using two murine models of stage IV breast cancer, we found that MWA of primary breast cancer inhibited the progression of lung metastasis and improved survival. NK cells were activated after MWA of the primary tumor and exhibited enhanced cytotoxic functions, and the cytotoxic pathways of NK cells were activated. Depletion experiments showed that NK cell

SUBMITTER: Yu M 

PROVIDER: S-EPMC8429677 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature