Early activation of the cardiac CX3CL1/CX3CR1 axis delays β-adrenergic-induced heart failure.

ABSTRACT: We recently highlighted a novel potential protective paracrine role of cardiac myeloid CD11b/c cells improving resistance of adult hypertrophied cardiomyocytes to oxidative stress and potentially delaying evolution towards heart failure (HF) in response to early β-adrenergic stimulation. Here we characterized macrophages (Mφ) in hearts early infused with isoproterenol as compared to control and failing hearts and evaluated the role of upregulated CX3CL1 in cardiac remodeling. Flow cytometry, immunohistology and Mφ-depletion experiments evidenced a transient increase in Mφ number in isoproterenol-infused hearts, proportional to early concentric hypertrophy (ECH) remodeling and limiting HF. Combining transcriptomic and secretomic approaches we characterized Mφ-enriched CD45⁺ cells

SUBMITTER: Flamant M 

PROVIDER: S-EPMC8429682 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature