Multimodal liquid biopsy for early monitoring and outcome prediction of chemotherapy in metastatic breast cancer.

ABSTRACT: Circulating tumor cells (CTCs) and circulating tumor DNA (ctDNA) are two cancer-derived blood biomarkers that inform on patient prognosis and treatment efficacy in breast cancer. We prospectively evaluated the clinical validity of quantifying both CTCs (CellSearch) and ctDNA (targeted next-generation sequencing). Their combined value as prognostic and early monitoring markers was assessed in 198 HER2-negative metastatic breast cancer patients. All patients were included in the prospective multicenter UCBG study COMET (NCT01745757) and treated by first-line chemotherapy with weekly paclitaxel and bevacizumab. Blood samples were obtained at baseline and before the second cycle of chemotherapy. At baseline, CTCs and ctDNA were respectively detected in 72 and 74% of patients and were moderatel

SUBMITTER: Bortolini Silveira A 

PROVIDER: S-EPMC8429692 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature