Effect of changes in inspired oxygen fraction on oxygen delivery during cardiac surgery: a substudy of the CARROT trial.

ABSTRACT: When hemoglobin (Hb) is fully saturated with oxygen, the additional gain in oxygen delivery (DO₂) achieved by increasing the fraction of inspired oxygen (FiO₂) is often considered clinically insignificant. In this study, we evaluated the change in DO₂, interrogated by mixed venous oxygen saturation (SvO₂), in response to a change in FiO₂ of 0.5 during cardiac surgery. When patients were hemodynamically stable, FiO₂ was alternated between 0.5 and 1.0 in on-pump cardiac surgery patients (pilot study), and between 0.3 and 0.8 in off-pump coronary artery bypass grafting patients (substudy of the CARROT trial). After the patient had stabilized, a blood gas analysis was performed to measure SvO₂. The observed change in

SUBMITTER: Nam K 

PROVIDER: S-EPMC8429729 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature