Effect of metformin treatment and its time of administration on joint capsular fibrosis induced by mouse knee immobilization.

ABSTRACT: Joint contracture leads to major patient discomfort. Metformin, one of the most extensively used oral drugs against type 2 diabetes has recently been found to suppress tissue fibrosis as well. However, its role in suppressing tissue fibrosis in joint contractures remains unknown. In this study, we examined the role of metformin treatment in suppressing joint capsular fibrosis and the most effective time of its administration. Joint capsular fibrosis was induced by immobilizing the knee joints of mice using splints and tapes. Metformin was administered intraperitoneally every alternate day after immobilization. Histological and immunohistochemical changes and expression of fibrosis-related genes were evaluated. Metformin treatment significantly suppressed fibrosis in joint capsules based on

SUBMITTER: Tokuda K 

PROVIDER: S-EPMC8429753 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature