Real-time precise microfluidic droplets label-sequencing combined in a velocity detection sensor.

ABSTRACT: Droplets microfluidics is broadening the range of Lab on a Chip solutions that, however, still suffer from the lack of an adequate level of integration of optical detection and sensors. In fact, droplets are currently monitored by imaging techniques, mostly limited by a time-consuming data post-processing and big data storage. This work aims to overcome this weakness, presenting a fully integrated opto-microfluidic platform able to detect, label and characterize droplets without the need for imaging techniques. It consists of optical waveguides arranged in a Mach Zehnder's configuration and a microfluidic circuit both coupled in the same substrate. As a proof of concept, the work demonstrates the performances of this opto-microfluidic platform in performing a complete and simultaneous sequ

SUBMITTER: Zamboni R 

PROVIDER: S-EPMC8429775 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature