Effects of Simulated Microgravity on the Physiology of Stenotrophomonas maltophilia and Multiomic Analysis.

ABSTRACT: Many studies have shown that the space environment plays a pivotal role in changing the characteristics of conditional pathogens, especially their pathogenicity and virulence. However, Stenotrophomonas maltophilia, a type of conditional pathogen that has shown to a gradual increase in clinical morbidity in recent years, has rarely been reported for its impact in space. In this study, S. maltophilia was exposed to a simulated microgravity (SMG) environment in high-aspect ratio rotating-wall vessel bioreactors for 14days, while the control group was exposed to the same bioreactors in a normal gravity (NG) environment. Then, combined phenotypic, genomic, transcriptomic, and proteomic analyses were conducted to compare the influence of the SMG and NG on S. maltophilia. The

SUBMITTER: Su X 

PROVIDER: S-EPMC8429793 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature