Landscape of Immune Microenvironment Under Immune Cell Infiltration Pattern in Breast Cancer.

ABSTRACT:

Background

Increasing evdence supports the suggestion that the immune cell infiltration (ICI) patterns play a pivotal role in tumor progression in breast cancer (BRCA). Nonetheless, there has been no comprehensive analysis of the ICI patterns effects on the clinical outcomes and immunotherapy.

Methods

Multiomic data for BRCA samples were downloaded from TCGA. ESTIMATE algorithm, ssGSEA method, and CIBERSORT analysis were used to uncover the landscape of the tumor immune microenvironment (TIME). BRCA subtypes based on the ICI pattern were identified by consensus clustering and principal-component analysis was performed to obtain the ICI scores to quantify the ICI patterns in individual tumors. Their prognostic value was validated by the Kaplan-Meier survival curves. Gene set

SUBMITTER: Xu Q 

PROVIDER: S-EPMC8429934 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature