Dissecting Tumor Antigens and Immune Subtypes of Glioma to Develop mRNA Vaccine.

ABSTRACT:

Background

Nowadays, researchers are leveraging the mRNA-based vaccine technology used to develop personalized immunotherapy for cancer. However, its application against glioma is still in its infancy. In this study, the applicable candidates were excavated for mRNA vaccine treatment in the perspective of immune regulation, and suitable glioma recipients with corresponding immune subtypes were further investigated.

Methods

The RNA-seq data and clinical information of 702 and 325 patients were recruited from TCGA and CGGA, separately. The genetic alteration profile was visualized and compared by cBioPortal. Then, we explored prognostic outcomes and immune correlations of the selected antigens to validate their clinical relevance. The prognostic index was measured via G

SUBMITTER: Zhong H 

PROVIDER: S-EPMC8429949 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature