Validating atlas-based lesion disconnectomics in multiple sclerosis: A retrospective multi-centric study.

ABSTRACT: The translational potential of MR-based connectivity modelling is limited by the need for advanced diffusion imaging, which is not part of clinical protocols for many diseases. In addition, where diffusion data is available, brain connectivity analyses rely on tractography algorithms which imply two major limitations. First, tracking algorithms are known to be sensitive to the presence of white matter lesions and therefore leading to interpretation pitfalls and poor inter-subject comparability in clinical applications such as multiple sclerosis. Second, tractography quality is highly dependent on the acquisition parameters of diffusion sequences, leading to a trade-off between acquisition time and tractography precision. Here, we propose an atlas-based approach to study the interplay betwe

SUBMITTER: Ravano V 

PROVIDER: S-EPMC8429972 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature