The association between polymorphisms in PITX2 and congenital esophageal atresia susceptibility.

ABSTRACT:

Objective

This study aims to investigate and analyze the connection between PITX2 polymorphisms and the susceptibility of congenital esophageal atresia.

Methods

From January 2015 to June 2020, 46 children with congenital esophageal atresia undergoing surgery were recruited for the study and placed in an observation group, and 40 neonates born in pediatrics during the same period were also recruited for the study and placed in a control group. The alleles and distribution frequencies of the polymorphisms of PITX2 gene rs2200733 were analyzed, and the odds ratio (OR) of esophageal atresia caused by the rs2200733 polymorphism were calculated using a logistic analysis.

Results

In the observation group, there were 23 patients (50.00%) with the TT genotype of rs2200733, 21

SUBMITTER: Ke J 

PROVIDER: S-EPMC8430062 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature