NRP2, a potential biomarker for oral squamous cell carcinoma.

ABSTRACT:

Background

Neuropilin-2 (NRP2) is a single chain transmembrane glycoprotein that acts as a co-receptor of VEGF and is related to the pathogenesis of various tumors closely. However, the clinical significance of NRP2 in oral squamous cell carcinoma (OSCC) is unclear.

Purpose

The objective of this study was to investigate the role of NRP2 in the pathogenesis of OSCC and explore the associated mechanisms.

Materials and methods

GEPIA (gene expression profiling interactive analysis) was used to analyze the expression of NRP2 in OSCC. Immunohistochemistry and RT-qPCR were used to detect NRP2 expression in 80 OSCC samples. The clinical correlations and prognostic significance of NRP2 expression were evaluated. In addition, the biological functions of OSCC cells transfected w

SUBMITTER: Kang Y 

PROVIDER: S-EPMC8430140 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature