Genomic instability in lower-grade glioma: Prediction of prognosis based on lncRNA and immune infiltration.

ABSTRACT: Glioma is the most common type of primary malignant tumor in the central nervous system. Tumor recurrence and progression are common in lower-grade glioma (LGG). Immune checkpoint blockade (ICB), as an emerging immunotherapy, is expected to improve the prognosis of patients undergoing conventional treatment, but it currently performs poorly in glioma. We divided patients into genome-stable and -unstable groups according to the somatic mutation count and then found that the expression of CDC20 was positively correlated with genomic instability. We compared the differences in long non-coding RNA (lncRNA) expression and immune infiltration between the two groups. Five lncRNAs and three immune cell types were identified to construct risk models and a nomogram combing clinical features.

SUBMITTER: Kang K 

PROVIDER: S-EPMC8430277 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature