Aberrant rich club organization in patients with obsessive-compulsive disorder and their unaffected first-degree relatives.

ABSTRACT: Recent studies suggested that the rich club organization promoting global brain communication and integration of information, may be abnormally increased in obsessive-compulsive disorder (OCD). However, the structural and functional basis of this organization is still not very clear. Given the heritability of OCD, as suggested by previous family-based studies, we hypothesize that aberrant rich club organization may be a trait marker for OCD. In the present study, 32 patients with OCD, 30 unaffected first-degree relatives (FDR) and 32 healthy controls (HC) underwent diffusion tensor imaging (DTI) and functional magnetic resonance imaging (fMRI). We examined the structural rich club organization and its interrelationship with functional coupling. Our results showed that rich club and periphe

SUBMITTER: Peng Z 

PROVIDER: S-EPMC8430383 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature