Directional Persistence of Cell Migration in Schizophrenia Patient-Derived Olfactory Cells.

ABSTRACT: Cell migration is critical for brain development and linked to several neurodevelopmental disorders, including schizophrenia. We have shown previously that cell migration is dysregulated in olfactory neural stem cells from people with schizophrenia. Although they moved faster than control cells on plastic substrates, patient cells were insensitive to regulation by extracellular matrix proteins, which increase the speeds of control cells. As well as speed, cell migration is also described by directional persistence, the straightness of movement. The aim of this study was to determine whether directional persistence is dysregulated in schizophrenia patient cells and whether it is modified on extracellular matrix proteins. Directional persistence in patient-derived and control-derived olfacto

SUBMITTER: Tee JY 

PROVIDER: S-EPMC8430705 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature