Oral Squamous Cell Carcinoma Contributes to Differentiation of Monocyte-Derived Tumor-Associated Macrophages via PAI-1 and IL-8 Production.

ABSTRACT: Tumor-associated macrophages (TAMs) promote cancer cell proliferation and metastasis, as well as anti-tumor immune suppression. Recent studies have shown that tumors enhance the recruitment and differentiation of TAMs, but the detailed mechanisms have not been clarified. We thus examined the influence of cancer cells on the differentiation of monocytes to TAM subsets, including CD163⁺, CD204⁺, and CD206⁺ cells, in oral squamous cell carcinoma (OSCC) using immunohistochemistry, flow cytometry, and a cytokine array. Furthermore, we investigated the effect of OSCC cells (HSC-2, SQUU-A, and SQUU-B cells) on the differentiation of purified CD14⁺ cells to TAM subsets. The localization patterns of CD163⁺, CD204⁺, and CD206⁺

SUBMITTER: Kai K 

PROVIDER: S-EPMC8430735 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature