Key Points in Remote-Controlled Drug Delivery: From the Carrier Design to Clinical Trials.

ABSTRACT: The increased research activity aiming at improved delivery of pharmaceutical molecules indicates the expansion of the field. An efficient therapeutic delivery approach is based on the optimal choice of drug-carrying vehicle, successful targeting, and payload release enabling the site-specific accumulation of the therapeutic molecules. However, designing the formulation endowed with the targeting properties in vitro does not guarantee its selective delivery in vivo. The various biological barriers that the carrier encounters upon intravascular administration should be adequately addressed in its overall design to reduce the off-target effects and unwanted toxicity in vivo and thereby enhance the therapeutic efficacy of the payload. Here, we discuss the main parameters of remote-controlled

SUBMITTER: Voronin DV 

PROVIDER: S-EPMC8430748 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature