Heat Stress Alters the Intestinal Microbiota and Metabolomic Profiles in Mice.

ABSTRACT:

Background

Heat stress has negative effects on the intestinal health of humans and animals. However, the impact of heat stress on intestinal microbial and metabolic changes remains elusive. Here, we investigated the cecal microbial and metabolic profiles in mice in response to heat stress.

Methods

The mouse heat stress model was constructed by simulating a high-temperature environment. Twenty mice were randomly assigned to two groups, the control group (CON, 25°C) and the heat treatment group (HS, 40°C from 13:00 to 15:00 every day for 7 days). Serum and cecal contents were collected from the mice for serum biochemical analysis, 16S rRNA high-throughput sequencing, and non-targeted metabolomics.

Results

Both core body temperature and water intake were significantly in

SUBMITTER: Wen C 

PROVIDER: S-EPMC8430895 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature