Trends in Late Mortality and Life Expectancy After Allogeneic Blood or Marrow Transplantation Over 4 Decades: A Blood or Marrow Transplant Survivor Study Report.

ABSTRACT:

Importance

The past 4 decades have seen substantial changes in allogeneic blood or marrow transplantation (BMT) practice, with the overarching goal of expanding the eligible patient pool while optimizing disease-free survival.

Objective

To determine trends in life expectancy and cause-specific late mortality after allogeneic BMT performed over a 40-year period.

Design, setting, and participants

A retrospective cohort study of 4741 individuals who lived 2 or more years after allogeneic BMT performed between January 1, 1974, and December 31, 2014, was conducted at City of Hope, University of Minnesota, or University of Alabama at Birmingham. The end of follow-up was March 23, 2020.

Exposures

Allogeneic BMT performed in 3 eras: 1974-1989, 1990-2004, and 2005-2014.

SUBMITTER: Bhatia S 

PROVIDER: S-EPMC8430905 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature