Canady Helios Cold Plasma Induces Breast Cancer Cell Death by Oxidation of Histone mRNA.

ABSTRACT: Breast cancer is the most common cancer among women worldwide. Its molecular receptor marker status and mutational subtypes complicate clinical therapies. Cold atmospheric plasma is a promising adjuvant therapy to selectively combat many cancers, including breast cancer, but not normal tissue; however, the underlying mechanisms remain unexplored. Here, four breast cancer cell lines with different marker status were treated with Canady Helios Cold Plasma™ (CHCP) at various dosages and their differential progress of apoptosis was monitored. Inhibition of cell proliferation, induction of apoptosis, and disruption of the cell cycle were observed. At least 16 histone mRNA types were oxidized and degraded immediately after CHCP treatment by 8-oxoguanine (8-oxoG) modification. The expression of D

SUBMITTER: Cheng X 

PROVIDER: S-EPMC8430908 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature