Tau Protein Interaction Partners and Their Roles in Alzheimer's Disease and Other Tauopathies.

ABSTRACT: Tau protein plays a critical role in the assembly, stabilization, and modulation of microtubules, which are important for the normal function of neurons and the brain. In diseased conditions, several pathological modifications of tau protein manifest. These changes lead to tau protein aggregation and the formation of paired helical filaments (PHF) and neurofibrillary tangles (NFT), which are common hallmarks of Alzheimer's disease and other tauopathies. The accumulation of PHFs and NFTs results in impairment of physiological functions, apoptosis, and neuronal loss, which is reflected as cognitive impairment, and in the late stages of the disease, leads to death. The causes of this pathological transformation of tau protein haven't been fully understood yet. In both physiological and pathol

SUBMITTER: Sinsky J 

PROVIDER: S-EPMC8431036 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature