Ontology highlight
ABSTRACT:
SUBMITTER: da Silva EZM
PROVIDER: S-EPMC8431081 | biostudies-literature | 2021 Aug
REPOSITORIES: biostudies-literature
da Silva Elaine Zayas Marcelino EZM Fraga-Silva Thais Fernanda de Campos TFC Yuan Yao Y Alves Márcia Gaião MG Publio Gabriel Azevedo GA da Fonseca Carol Kobori CK Kodama Márcio Hideki MH Vieira Gabriel Viliod GV Candido Marina Ferreira MF Innocentini Lara Maria Alencar Ramos LMAR Miranda Mateus Gonçalves MG da Silva Alfredo Ribeiro AR Alves-Filho Jose Carlos JC Bonato Vania Luiza Deperon VLD Iglesias-Bartolome Ramiro R Sales Katiuchia Uzzun KU
Cancers 20210831 17
Head and neck squamous cell carcinoma remains challenging to treat with no improvement in survival rates over the past 50 years. Thus, there is an urgent need to discover more reliable therapeutic targets and biomarkers for HNSCC. Matriptase, a type-II transmembrane serine protease, induces malignant transformation in epithelial stem cells through proteolytic activation of pro-HGF and PAR-2, triggering PI3K-AKT-mTOR and NFKB signaling. The serine protease inhibitor lympho-epithelial Kazal-type-r ...[more]