Enzyme Therapy: Current Challenges and Future Perspectives.

ABSTRACT: In recent years, enzymes have risen as promising therapeutic tools for different pathologies, from metabolic deficiencies, such as fibrosis conditions, ocular pathologies or joint problems, to cancer or cardiovascular diseases. Treatments based on the catalytic activity of enzymes are able to convert a wide range of target molecules to restore the correct physiological metabolism. These treatments present several advantages compared to established therapeutic approaches thanks to their affinity and specificity properties. However, enzymes present some challenges, such as short in vivo half-life, lack of targeted action and, in particular, patient immune system reaction against the enzyme. For this reason, it is important to monitor serum immune response during treatment. This can be achiev

SUBMITTER: de la Fuente M 

PROVIDER: S-EPMC8431097 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature