Injectable Thixotropic β-Cyclodextrin-Functionalized Hydrogels Based on Guanosine Quartet Assembly.

ABSTRACT: Facile method for the preparation of β-cyclodextrin-functionalized hydrogels based on guanosine quartet assembly was described. A series of seven hydrogels were prepared by linking β-cyclodextrin molecules with guanosine moieties in different ratios through benzene-1,4-diboronic acid linker in the presence of potassium hydroxide. The potassium ions acted as a reticulation agent by forming guanosine quartets, leading to the formation of self-sustained transparent hydrogels. The ratios of the β-cyclodextrin and guanosine components have a significant effect on the internal structuration of the components and, correspondingly, on the mechanical properties of the final gels, offering a tunablity of the system by varying the components ratio. The insights into the hydrogels' structuration were

SUBMITTER: Sardaru MC 

PROVIDER: S-EPMC8431444 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature