Identifying the Main Functional Pathways Associated with Cognitive Resilience to Alzheimer's Disease.

ABSTRACT: Understanding the mechanisms involved in cognitive resilience in Alzheimer's disease (AD) represents a promising strategy to identify novel treatments for dementia in AD. Previous findings from our group revealed that the study of aged-Tg2576 cognitive resilient individuals is a suitable tool for this purpose. In the present study, we performed a transcriptomic analysis using the prefrontal cortex of demented and resilient Tg2576 transgenic AD mice. We have been able to hypothesize that pathways involved in inflammation, amyloid degradation, memory function, and neurotransmission may be playing a role on cognitive resilience in AD. Intriguingly, the results obtained in this study are suggestive of a reduction of the influx of peripheral immune cells into the brain on cognitive resilient su

SUBMITTER: Perez-Gonzalez M 

PROVIDER: S-EPMC8431458 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature