Design and Characterization of a Cell-Penetrating Peptide Derived from the SOX2 Transcription Factor.

ABSTRACT: SOX2 is an oncogenic transcription factor overexpressed in nearly half of the basal-like triple-negative breast cancers associated with very poor outcomes. Targeting and inhibiting SOX2 is clinically relevant as high SOX2 mRNA levels are positively correlated with decreased overall survival and progression-free survival in patients affected with breast cancer. Given its key role as a master regulator of cell proliferation, SOX2 represents an important scaffold for the engineering of dominant-negative synthetic DNA-binding domains (DBDs) that act by blocking or interfering with the oncogenic activity of the endogenous transcription factor in cancer cells. We have synthesized an interference peptide (iPep) encompassing a truncated 24 amino acid long C-terminus of SOX2 containing a potential

SUBMITTER: Gandhi NS 

PROVIDER: S-EPMC8431565 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature