Mechanisms of Binding Specificity among bHLH Transcription Factors.

ABSTRACT: The transcriptome of every cell is orchestrated by the complex network of interaction between transcription factors (TFs) and their binding sites on DNA. Disruption of this network can result in many forms of organism malfunction but also can be the substrate of positive natural selection. However, understanding the specific determinants of each of these individual TF-DNA interactions is a challenging task as it requires integrating the multiple possible mechanisms by which a given TF ends up interacting with a specific genomic region. These mechanisms include DNA motif preferences, which can be determined by nucleotide sequence but also by DNA's shape; post-translational modifications of the TF, such as phosphorylation; and dimerization partners and co-factors, which can mediate multiple

SUBMITTER: de Martin X 

PROVIDER: S-EPMC8431614 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature