Targeting S1PR1 May Result in Enhanced Migration of Cancer Cells in Bladder Carcinoma.

ABSTRACT: Clinical bladder tumor histological analysis shows that high expression of S1PR1 is associated with poor patient prognosis. However, there are no studies that describe the underlying mechanism. To investigate the relative distribution and actual function of S1PR1 in bladder tumors, we analyzed multiple clinical databases in combination with tumor purity and immune cell infiltration simulations, as well as databases of well-defined histological phenotypes of bladder cancer, and single-cell sequencing of adjacent normal tissues and bladder tumors, and further compared them with bladder cancer cell lines. The results showed that S1PR1 expression was generally higher in normal tissues than in bladder cancer tissues, and its distribution was mainly in endothelial cel

SUBMITTER: Chen CL 

PROVIDER: S-EPMC8431630 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature