Mood Stabilizers in Psychiatric Disorders and Mechanisms Learnt from In Vitro Model Systems.

ABSTRACT: Bipolar disorder (BD) and schizophrenia are psychiatric disorders that manifest unusual mental, behavioral, and emotional patterns leading to suffering and disability. These disorders span heterogeneous conditions with variable heredity and elusive pathophysiology. Mood stabilizers such as lithium and valproic acid (VPA) have been shown to be effective in BD and, to some extent in schizophrenia. This review highlights the efficacy of lithium and VPA treatment in several randomized, controlled human trials conducted in patients suffering from BD and schizophrenia. Furthermore, we also address the importance of using induced pluripotent stem cells (iPSCs) as a disease model for mirroring the disease's phenotypes. In BD, iPSC-derived neurons enabled finding an endophenotype of hyperexcitabili

SUBMITTER: Nayak R 

PROVIDER: S-EPMC8431659 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature