Insights from IgE Immune Surveillance in Allergy and Cancer for Anti-Tumour IgE Treatments.

ABSTRACT: IgE, the predominant antibody class of the allergic response, is known for its roles in protecting against parasites; however, a growing body of evidence indicates a significant role for IgE and its associated effector cells in tumour immunosurveillance, highlighted by the field of AllergoOncology and the successes of the first-in-class IgE cancer therapeutic MOv18. Supporting this concept, substantial epidemiological data ascribe potential roles for IgE, allergy, and atopy in protecting against specific tumour types, with a corresponding increased cancer risk associated with IgE immunodeficiency. Here, we consider how epidemiological data in combination with functional data reveals a complex interplay of IgE and allergy with cancer, which cannot be explained solely by one of the existing

SUBMITTER: McCraw AJ 

PROVIDER: S-EPMC8431713 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature