Platelet transcriptome profiles provide potential therapeutic targets for elderly acute myelocytic leukemia patients.

ABSTRACT:

Background

Acute myeloid leukemia (AML) is the most common acute leukemia in adults, with a median age of 68 in clinical diagnosis. About 60% patients are over 60 years old. There are various treatment options for AML patients. But for elderly patients, the complete remission rates are disappointing due to genetic, molecular, and age-related factors. Development of next-generation sequencing technologies makes it possible to seek individual strategies for patients in different ages. This study analyzed transcriptome profiles in platelets of AML patients in different ages for the first time.

Methods

Platelet RNA sequencing in AML of ten elderly and seven young patients were performed with Illumina TruSeq Stranded mRNA library Prep Kit and Illumina HiSeq4000 sequencing instrum

SUBMITTER: Bao J 

PROVIDER: S-EPMC8431913 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature